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Chemical Structure : Belinostat
CAS No.: 866323-14-0
Catalog No.: PC-42469Not For Human Use, Lab Use Only.
Belinostat (PXD101, PX105684) is a potent HDAC inhibitor with IC50 of 27 nM (HeLa cell extracts).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $148 | In stock | |
| 50 mg | $228 | In stock | |
| 100 mg | $388 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Belinostat (PXD101, PX105684) is a potent HDAC inhibitor with IC50 of 27 nM (HeLa cell extracts).
Belinostat (PXD101, PX105684) inhibits histone deacetylase activity in cell lysates with IC50 of 9-100 nM, increases the acetylation of histone H4 and induces apoptosis in tumor cell lines.
Belinostat (PXD101, PX105684) inhibits the growth of a range of human tumor cell lines in vitro (IC50=0.2-3.4 uM).
Belinostat (PXD101, PX105684) shows antitumor activity in vivo with no apparent toxicity.
| M.Wt | 318.3477 | |
| Formula | C15H14N2O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-Propenamide, N-hydroxy-3-[3-[(phenylamino)sulfonyl]phenyl]-, (2E)- |
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1. Plumb JA, et al. Mol Cancer Ther. 2003 Aug;2(8):721-8.
2. Qian X, et al. Mol Cancer Ther. 2006 Aug;5(8):2086-95.
3. Buckley MT, et al. J Transl Med. 2007 Oct 12;5:49.
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