Belinostat (PXD101, PX105684) is a potent HDAC inhibitor with IC50 of 27 nM (HeLa cell extracts).
Belinostat (PXD101, PX105684) inhibits histone deacetylase activity in cell lysates with IC50 of 9-100 nM, increases the acetylation of histone H4 and induces apoptosis in tumor cell lines.
Belinostat (PXD101, PX105684) inhibits the growth of a range of human tumor cell lines in vitro (IC50=0.2-3.4 uM).
Belinostat (PXD101, PX105684) shows antitumor activity in vivo with no apparent toxicity.
