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Chemical Structure : Belizatinib
CAS No.: 1357920-84-3
Catalog No.: PC-70256Not For Human Use, Lab Use Only.
Belizatinib (TSR-011) is a potent, dual ALK and TrkA, TrkB and TrkC inhibitor, exhibits high affinity for wild-type recombinant ALK kinase activity with IC50 of 0.7 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $138 | In stock | |
| 25 mg | $228 | In stock | |
| 50 mg | $378 | In stock | |
| 100 mg | Get quote |
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Belizatinib (TSR-011) is a potent, dual ALK and TrkA, TrkB and TrkC inhibitor, exhibits high affinity for wild-type recombinant ALK kinase activity with IC50 of 0.7 nM.
Belizatinib (TSR-011) exerts sustained potent inhibition of ALK-dependent tumour growth in mouse models.
| M.Wt | 577.745 | |
| Formula | C33H44FN5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-fluoro-N-(6-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-1-((1s,4s)-4-(isopropylcarbamoyl)cyclohexyl)-1H-benzo[d]imidazol-2-yl)benzamide |
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1. Sullivan I, et al. Ther Adv Med Oncol. 2016 Jan;8(1):32-47.
2. Iams WT, et al. Cancer J. 2015 Sep-Oct;21(5):378-82.
3. Khotskaya YB, et al. Pharmacol Ther. 2017 May;173:58-66.
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