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Belizatinib

Chemical Structure : Belizatinib

CAS No.: 1357920-84-3

Belizatinib (TSR-011, TSR011)

Catalog No.: PC-70256Not For Human Use, Lab Use Only.

Belizatinib (TSR-011) is a potent, dual ALK and TrkA, TrkB and TrkC inhibitor, exhibits high affinity for wild-type recombinant ALK kinase activity with IC50 of 0.7 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Belizatinib (TSR-011) is a potent, dual ALK and TrkA, TrkB and TrkC inhibitor, exhibits high affinity for wild-type recombinant ALK kinase activity with IC50 of 0.7 nM.
Belizatinib (TSR-011) exerts sustained potent inhibition of ALK-dependent tumour growth in mouse models.

Physicochemical Properties

M.Wt 577.745
Formula C33H44FN5O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-fluoro-N-(6-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-1-((1s,4s)-4-(isopropylcarbamoyl)cyclohexyl)-1H-benzo[d]imidazol-2-yl)benzamide

References

1. Sullivan I, et al. Ther Adv Med Oncol. 2016 Jan;8(1):32-47.

2. Iams WT, et al. Cancer J. 2015 Sep-Oct;21(5):378-82.

3. Khotskaya YB, et al. Pharmacol Ther. 2017 May;173:58-66.

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