You are here:Home-Chemical Inhibitors & Agonists-Tyrosine Kinase-Trk Receptor-Belizatinib
Belizatinib

Chemical Structure : Belizatinib

CAS No.: 1357920-84-3

Belizatinib (TSR-011, TSR011)

Catalog No.: PC-70256Not For Human Use, Lab Use Only.

Belizatinib (TSR-011) is a potent, dual ALK and TrkA, TrkB and TrkC inhibitor, exhibits high affinity for wild-type recombinant ALK kinase activity with IC50 of 0.7 nM.

Packing Price Stock Quantity
5 mg $88 In stock
10 mg $138 In stock
25 mg $228 In stock
50 mg $378 In stock
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Belizatinib (TSR-011) is a potent, dual ALK and TrkA, TrkB and TrkC inhibitor, exhibits high affinity for wild-type recombinant ALK kinase activity with IC50 of 0.7 nM.
Belizatinib (TSR-011) exerts sustained potent inhibition of ALK-dependent tumour growth in mouse models.

Physicochemical Properties

M.Wt 577.745
Formula C33H44FN5O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-fluoro-N-(6-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-1-((1s,4s)-4-(isopropylcarbamoyl)cyclohexyl)-1H-benzo[d]imidazol-2-yl)benzamide

References

1. Sullivan I, et al. Ther Adv Med Oncol. 2016 Jan;8(1):32-47.

2. Iams WT, et al. Cancer J. 2015 Sep-Oct;21(5):378-82.

3. Khotskaya YB, et al. Pharmacol Ther. 2017 May;173:58-66.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: