Beloranib hemioxalate | MetAP2 inhibitor

Chemical Structure : Beloranib hemioxalate

Beloranib hemioxalate (CKD-732, ZGN-433)

Catalog No.: PC-61442Not For Human Use, Lab Use Only.

Beloranib hemioxalate (CKD-732, ZGN-433) is an analog of the natural compound Fumagillin that functions as a highly potent methionine aminopeptidase 2 (MetAP2) inhibitor.

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Biological Activity

Beloranib hemioxalate (CKD-732, ZGN-433) is an analog of the natural compound Fumagillin that functions as a highly potent methionine aminopeptidase 2 (MetAP2) inhibitor.
Beloranib strongly inhibit the growth of cancers in xenografted nude model.
Beloranib also causes significant body weight and appetite reduction an anti-obesity agent.

Physicochemical Properties

M.Wt	589.682
Formula	C31H43NO10
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3R,4S,5S,6R)-5-methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yl (E)-3-(4-(2-(dimethylamino)ethoxy)phenyl)acrylate oxalate

References

1. Kim YM, et al. J Mol Endocrinol. 2007 Apr;38(4):455-65.

2. Morgen M, et al. ACS Chem Biol. 2016 Apr 15;11(4):1001-11.

3. Chun E, et al. Int J Cancer. 2005 Mar 10;114(1):124-30.

4. Hughes TE, et al. Obesity (Silver Spring). 2013 Sep;21(9):1782-8.

Beloranib hemioxalate (CKD-732, ZGN-433)

Biological Activity

Physicochemical Properties

References

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