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Chemical Structure : Bempedoic acid
CAS No.: 738606-46-7
Catalog No.: PC-43001Not For Human Use, Lab Use Only.
Bempedoic acid (ESP-55016; ETC-1002) is a small molecule regulator of lipid and carbohydrate metabolism, inhibits ATP Citrate Lyase (ACL, ACLY).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $128 | In stock | |
| 50 mg | $198 | In stock | |
| 100 mg | $298 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Bempedoic acid (ESP-55016; ETC-1002) is a small molecule regulator of lipid and carbohydrate metabolism, inhibits ATP Citrate Lyase (ACL, ACLY).
Bempedoic acid activates AMP-activated protein kinase in a Ca2+/calmodulin-dependent kinase β-independent and liver kinase β 1-dependent manner
Bempedoic acid targets ACC (acetyl-CoA carboxylase) with IC50 of 29 uM without activating the AMPK pathway in vitro.
Bempedoic acid reduces circulating proatherogenic lipoproteins, hepatic lipids, and body weight in a hamster model of hyperlipidemia.
| M.Wt | 344.4861 | |
| Formula | C19H36O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Pentadecanedioic acid, 8-hydroxy-2,2,14,14-tetramethyl- |
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1. Pinkosky SL, et al. J Lipid Res. 2013 Jan;54(1):134-51.
2. Cramer CT, et al. J Lipid Res. 2004 Jul;45(7):1289-301.
3. Filippov S, et al. J Lipid Res. 2013 Aug;54(8):2095-108.
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