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Bempedoic acid

Chemical Structure : Bempedoic acid

CAS No.: 738606-46-7

Bempedoic acid (ESP-55016;ETC-1002)

Catalog No.: PC-43001Not For Human Use, Lab Use Only.

Bempedoic acid (ESP-55016; ETC-1002) is a small molecule regulator of lipid and carbohydrate metabolism, inhibits ATP Citrate Lyase (ACL, ACLY).

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Biological Activity

Bempedoic acid (ESP-55016; ETC-1002) is a small molecule regulator of lipid and carbohydrate metabolism, inhibits ATP Citrate Lyase (ACL, ACLY).
Bempedoic acid activates AMP-activated protein kinase in a Ca2+/calmodulin-dependent kinase β-independent and liver kinase β 1-dependent manner
Bempedoic acid targets ACC (acetyl-CoA carboxylase) with IC50 of 29 uM without activating the AMPK pathway in vitro.
Bempedoic acid reduces circulating proatherogenic lipoproteins, hepatic lipids, and body weight in a hamster model of hyperlipidemia.

Physicochemical Properties

M.Wt 344.4861
Formula C19H36O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Pentadecanedioic acid, 8-hydroxy-2,2,14,14-tetramethyl-

References

1. Pinkosky SL, et al. J Lipid Res. 2013 Jan;54(1):134-51.

2. Cramer CT, et al. J Lipid Res. 2004 Jul;45(7):1289-301.

3. Filippov S, et al. J Lipid Res. 2013 Aug;54(8):2095-108.

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