Benvitimod (GSK-2894512, Tapinarof) is a natural aryl hydrocarbon receptor (AhR) agonist with anti-inflammatory properties.
Benvitimod binds and activates AhR in multiple cell types, moderates proinflammatory cytokine expression in stimulated peripheral blood CD4+ T cells and ex vivo human skin, and impacts barrier gene expression in primary human keratinocytes.
Benvitimod shows no impact on imiquimod-induced skin inflammation in AhR-deficient mice.
Physicochemical Properties
M.Wt
254.329
Formula
C17H18O2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
3,5-Dihydroxy-4-isopropylstilbene
References
1. Bissonnette R, et al. Arch Dermatol. 2010 Apr;146(4):446-9.
