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Benzamil hydrochloride

Chemical Structure : Benzamil hydrochloride

CAS No.: 161804-20-2

Benzamil hydrochloride (Benzylamiloride hydrochloride)

Catalog No.: PC-23671Not For Human Use, Lab Use Only.

Benzamil hydrochloride (Benzylamiloride hydrochloride) is an Amiloride analogue and Na+/Ca2+ exchanger (NCX) inhibitor with IC50 of 100 nM, also is a non-selective Deg/epithelial sodium channels (ENaC) blocker.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Benzamil hydrochloride (Benzylamiloride hydrochloride) is an Amiloride analogue and Na+/Ca2+ exchanger (NCX) inhibitor with IC50 of 100 nM, also is a non-selective Deg/epithelial sodium channels (ENaC) blocker.
Benzamil hydrochloride inhibits TRPP3-mediated Ca2+-activated currents with IC50 of 1.1 uM.
Benzamil hydrochloride could potentiate myogenic vasoconstriction.

Physicochemical Properties

M.Wt 356.21
Formula C13H15Cl2N7O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3,5-Diamino-N-(N-benzylcarbamimidoyl)-6-chloropyrazine-2-carboxamide hydrochloride

References

1. Fischer KG, et al.Nephrol Dial Transplant. 2002 Oct;17(10):1742-50.

2. Dai XQ, et al. Mol Pharmacol. 2007 Dec;72(6):1576-85.

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