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Chemical Structure : Benzbromarone
CAS No.: 3562-84-3
Catalog No.: PC-47187Not For Human Use, Lab Use Only.
Benzbromarone (NSC 85433, MJ10061) is a small molecule inhibitor of Eyes Absen (EYA) protein tyrosine phosphatase activity (IC50=8.3 uM, EYA3), exhibits selectivity for EYA over PTP1B.
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Benzbromarone (NSC 85433, MJ10061) is a small molecule inhibitor of Eyes Absen (EYA) protein tyrosine phosphatase activity (IC50=8.3 uM, EYA3), exhibits selectivity for EYA over PTP1B.
Benzbromarone is an inhibitor of the urate anion transporter (IC50=0.3 uM for hURAT1) that prevents renal urate resorption.
Benzbromarone also is a small-molecule blocker of TMEM16A-CaCC channels, significantly impairs mucus secretion in primary human airway surface epithelial cells.
Benzbromarone blocks calcium-activated chloride channel (CaCC) TMEM16A with IC50 of 9.97 uM in HEK293 cells.
| M.Wt | 424.0834 | |
| Formula | C17H12Br2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 39 mg/mL |
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| Chemical Name/SMILES |
Methanone, (3,5-dibromo-4-hydroxyphenyl)(2-ethyl-3-benzofuranyl)- |
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1. Sinclair DS, et al. J Rheumatol. 1975 Dec;2(4):437-45.
2. Kumar V, et al. Drug Metab Dispos. 2006 Oct;34(10):1688-96. Epub 2006 Jun 30.
3. Huang F, et al. Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16354-9.
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