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Chemical Structure : Bersacapavir
Catalog No.: PC-20253Not For Human Use, Lab Use Only.
Bersacapavir (JNJ 56136379, JNJ-6379) is a potent HBV capsid assembly modulator, JNJ-6379 specifically and potently inhibits HBV replication with EC50 of 54 nM (HepG2.117 cells).
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Bersacapavir (JNJ 56136379, JNJ-6379) is a potent HBV capsid assembly modulator, JNJ-6379 specifically and potently inhibits HBV replication with EC50 of 54 nM (HepG2.117 cells).
Bersacapavir (JNJ 56136379, JNJ-6379) dose-dependently reduced extracellular HBV DNA levels (median EC50 of 93 nM) and prevented covalently closed circular DNA (cccDNA) formation.
Bersacapavir (JNJ 56136379, JNJ-6379) reduced intracellular HBV RNA levels (median EC50 of 876 nM) and reduced antigen levels in HBV-infected primary human hepatocytes (PHHs).
| M.Wt | 418.37 | |
| Formula | C16H14F4N4O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Berke JM, et al. Antimicrob Agents Chemother. 2020 Apr 21;64(5):e02439-19.
2. Zoulim F, et al. Gastroenterology. 2020 Aug;159(2):521-533.e9.
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