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Berubicin

Chemical Structure : Berubicin

CAS No.: 677017-23-1

Berubicin (WP744, RTA744)

Catalog No.: PC-28246Not For Human Use, Lab Use Only.

Berubicin (WP744, RTA744) is a doxorubicin analog that can penetrate and cross the blood-brain barrier, preserving DNA binding and acting as a potent topoisomerase II poison.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Berubicin (WP744, RTA744) is a doxorubicin analog that can penetrate and cross the blood-brain barrier, preserving DNA binding and acting as a potent topoisomerase II poison.

Physicochemical Properties

M.Wt 633.65
Formula C34H35NO11
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(8S,10S)-10-(((2R,4S,5S,6S)-4-amino-5-(benzyloxy)-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione

References

1. Mikaelian G, et al. J Phys Chem B. 2024 Jul 4;128(26):6291-6307.

2. Conrad CA, et al. Neurooncol Adv. 2026 Jul 31;8(1):vdag150.

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