Chemical Structure : Betovumeline hydrochloride
CAS No.:
1364078-75-0
Betovumeline hydrochloride
(ML-007 hydrochloride, MPL-0527 hydrochloride)
Catalog No.: PC-28083Not For Human Use, Lab Use Only.
Betovumeline hydrochloride (ML-007, MPL-0527) is a potent brain-penetrant agonist at both M1 and M4 muscarinic receptors with EC50 of 120 and 830 nM for huamn M1 and M4 receptors, 340 and 1600 nM for rat M1 and M4 receptors.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Betovumeline hydrochloride (ML-007, MPL-0527) is a potent brain-penetrant agonist at both M1 and M4 muscarinic receptors with EC50 of 120 and 830 nM for huamn M1 and M4 receptors, 340 and 1600 nM for rat M1 and M4 receptors.
ML-007 has demonstrated compelling efficacy across a range of preclinical models of psychosis in schizophrenia including amphetamine-induced hyperlocomotion, PCP-induced hyperlocomotion, and conditioned avoidance response.
ML-007 is approximately ten-fold more potent than the comparator xanomeline.
Physicochemical Properties
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M.Wt
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201.65
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Formula
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C8H12ClN3O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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5-((1R,5R)-3-azabicyclo[3.1.0]hexan-1-yl)-3-methyl-1,2,4-oxadiazole hydrochloride
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References
1. Chatterjee S, et al. Neuropsychopharmacology. 2025 Oct 4. doi: 10.1038/s41386-025-02256-3.
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