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Chemical Structure : Bexagliflozin
CAS No.: 1118567-05-7
Catalog No.: PC-45385Not For Human Use, Lab Use Only.
Bexagliflozin (THR-1442, EGT1442) is a potent and selective SGLT2 inhibitor with IC50 of 2 nM.
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| 50 mg | $578 | In stock | |
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Bexagliflozin (THR-1442, EGT1442) is a potent and selective SGLT2 inhibitor with IC50 of 2 nM.
Bexagliflozin shows little activity for SGLT1 (IC50=5.6 uM).
Bexagliflozin produces a saturable urinary glucose excretion in normal rats and dogs with ED50 of 0.38 and 0.09mg/kg, respectively.
Bexagliflozin reduced HbA(1c) and blood glucose concentration without affecting body mass or insulin level in db/db mice.
| M.Wt | 464.9359 | |
| Formula | C24H29ClO7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
D-Glucitol, 1,5-anhydro-1-C-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-, (1S)- |
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1. Wang L, et al. Xenobiotica. 2016 Aug;46(8):703-8.
2. Zhang W, et al. Pharmacol Res. 2011 Apr;63(4):284-93.
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