Chemical Structure : Bexotegrast
CAS No.:
2376257-44-0
Bexotegrast
(PLN-74809, PLN74809)
Catalog No.: PC-73406Not For Human Use, Lab Use Only.
Bexotegrast (PLN-74809) is an orally active, potent dual αvβ6/αvβ1 integrin inhibitor with Kd of 5.7 nM and 3.4 nM, respectively.
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Purity & Documentation Purity:
>98% (HPLC)
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Biological Activity
Bexotegrast (PLN-74809) is an orally active, potent dual αvβ6/αvβ1 integrin inhibitor with Kd of 5.7 nM and 3.4 nM, respectively.
Bexotegrast (PLN-74809) inhibits αvβ6- and αvβ1-induced TGF-β activation with IC50 values of 29.8 nM and 19.2 nM, respectively.
Bexotegrast (PLN-74809) has antifibrogenic effects and block multiple avenues of TGF-β activation in the fibrotic lung.
Physicochemical Properties
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M.Wt
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492.624
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Formula
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C27H36N6O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S)-4-((2-methoxyethyl)(4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butyl)amino)-2-(quinazolin-4-ylamino)butanoic acid
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References
1. Anindya Roy, et al. Nat Commun. 2023 Sep 13;14(1):5660.
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