Catalog No.: PC-21972Not For Human Use, Lab Use Only.
Bezisterim (HE3286, NE3107) is an orally bioavailable synthetic analogue of an active DHEA metabolite, displays both glucose-lowering and cholesterol-lowering effects, inhibits inflammatory NF-κB transcription, and confers oral bioavailability and blood-brain barrier permeability.
Bezisterim (HE3286, NE3107) is an orally bioavailable synthetic analogue of an active DHEA metabolite, displays both glucose-lowering and cholesterol-lowering effects, inhibits inflammatory NF-κB transcription, and confers oral bioavailability and blood-brain barrier permeability.
Bezisterim (HE3286) attenuates LPS- and TNFalpha-stimulated inflammation in primary murine macrophages.
Bezisterim (HE3286) downregulates inflammatory cytokine/chemokine expression in liver and adipose tissue of Zucker diabetic fatty rats.
Physicochemical Properties
M.Wt
330.47
Formula
C21H30O3
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
17alpha-pregn-5-en-20-yne-3beta,7beta,17-triol
References
1. Kosiewicz MM, et al. Eur J Pharmacol. 2011 May 11;658(2-3):257-62.
2. Wang T, et al. J Pharmacol Exp Ther. 2010 Apr;333(1):70-80.
