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Bezisterim

Chemical Structure : Bezisterim

CAS No.: 1001100-69-1

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Bezisterim (HE3286)

Catalog No.: PC-21972Not For Human Use, Lab Use Only.

Bezisterim (HE3286) is an orally bioavailable synthetic analogue of an active DHEA metabolite, displays both glucose-lowering and cholesterol-lowering effects.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Bezisterim (HE3286) is an orally bioavailable synthetic analogue of an active DHEA metabolite, displays both glucose-lowering and cholesterol-lowering effects.
Bezisterim (HE3286) attenuates LPS- and TNFalpha-stimulated inflammation in primary murine macrophages.
Bezisterim (HE3286) downregulates inflammatory cytokine/chemokine expression in liver and adipose tissue of Zucker diabetic fatty rats.

Physicochemical Properties

M.Wt 330.47
Formula C21H30O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

17alpha-pregn-5-en-20-yne-3beta,7beta,17-triol

References

1. Kosiewicz MM, et al. Eur J Pharmacol. 2011 May 11;658(2-3):257-62.

2. Wang T, et al. J Pharmacol Exp Ther. 2010 Apr;333(1):70-80.

3. Offner H, et al. J Pharmacol Exp Ther. 2009 Jun;329(3):1100-9.

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