Bfl-1 inhibitor 25

Chemical Structure : Bfl-1 inhibitor 25

Catalog No.: PC-26239Not For Human Use, Lab Use Only.

Bfl-1 inhibitor 25 is a potent and irreversible cellular probe inhibitor of Bcl-2 family member Bfl-1 with FRET IC50 of 16 nM, inhibits SU-DHL-1 cell viability with EC50 of 0.21 uM.

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Biological Activity

Bfl-1 inhibitor 25 is a potent and irreversible cellular probe inhibitor of Bcl-2 family member Bfl-1 with FRET IC50 of 16 nM, inhibits SU-DHL-1 cell viability with EC50 of 0.21 uM.

Physicochemical Properties

M.Wt	461.49
Formula	C24H26F3N3O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R,2R)-2-Amino-N-(4-((R)-1-(N-(4-(trifluoromethoxy)phenyl)acrylamido)ethyl)phenyl)cyclopentane-1-Carboxamide

References

1. J Henry Blackwell, et al. J Med Chem. 2026 Jan 22;69(2):1218-1246.

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