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Bifonazole

Chemical Structure : Bifonazole

CAS No.: 60628-96-8

Bifonazole (Bay H-4502)

Catalog No.: PC-27949Not For Human Use, Lab Use Only.

Bifonazole (Bay H-4502) is an imidazole antifungal agent that inhibits ergosterol biosynthesis via specifically targets fungal lanosterol 14α-demethylase (CYP51A1), also is a SARS-CoV-2 blocking agent that binds ACE2 and prevents association with the RBD, affecting entry and replication of spike-pseudotyped viruses as well as native SARS-CoV-2 and its variants of concern (VOCs).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Bifonazole (Bay H-4502) is an imidazole antifungal agent that inhibits ergosterol biosynthesis via specifically targets fungal lanosterol 14α-demethylase (CYP51A1), also is a SARS-CoV-2 blocking agent that binds ACE2 and prevents association with the RBD, affecting entry and replication of spike-pseudotyped viruses as well as native SARS-CoV-2 and its variants of concern (VOCs).

Physicochemical Properties

M.Wt 310.40
Formula C22H18N2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-([1,1'-Biphenyl]-4-yl(phenyl)methyl)-1H-imidazole

References

1. Barug D, et al. Arzneimittelforschung. 1983;33(4):524-8.

2. Taha Z, et al. Mol Ther. 2022 Sep 7;30(9):2998-3016.

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