Chemical Structure : BioA inhibitor C48
CAS No.:
BioA inhibitor C48
Catalog No.: PC-25836Not For Human Use, Lab Use Only.
BioA inhibitor C48 is a potent and selective inhibitor of bacterial aminotransferase BioA, a key enzyme in bacterial biotin biosynthesis, with Ki of 200 pM, displays sub-micromolar MICs against Mycobacterium tuberculosis (Mtb, H37Rv MIC50=93 nM) and nontuberculous mycobacteria.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
BioA inhibitor C48 is a potent and selective inhibitor of bacterial aminotransferase BioA, a key enzyme in bacterial biotin biosynthesis, with Ki of 200 pM, displays sub-micromolar MICs against Mycobacterium tuberculosis (Mtb, H37Rv MIC50=93 nM) and nontuberculous mycobacteria.
C48 induces cell envelope stress and membrane remodeling, mimicking biotin starvation.
C48 has IC50 of 34 nM in BioA inhibition assays.
C48 reduced Mtb burden in lungs and spleen in murine infection models.
Physicochemical Properties
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M.Wt
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418.27
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Formula
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C19H17BrFN3O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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3-(4-(3-bromo-4-fluorobenzoyl)piperazin-1-yl)-5,6-dihydro-7H-cyclopenta[c]pyridin-7-one
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References
1. Qiang Liu, et al. bioRxiv [Preprint]. 2025 Sep 24:2025.09.24.678246.
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