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Bioymifi

Chemical Structure : Bioymifi

CAS No.: 1420071-30-2

Bioymifi (DR5 activator)

Catalog No.: PC-45466Not For Human Use, Lab Use Only.

Bioymifi is a potent small-molecule activatior of the TRAIL receptor DR5, directly binds to DR5 with Kd of 1.2 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Bioymifi is a potent small-molecule activatior of the TRAIL receptor DR5, directly binds to DR5 with Kd of 1.2 uM.
Bioymifi shows little binding affinity to the DR4 ECD.
Bioymifi promotes DR5 aggregation, activation and induces apoptosis.

Physicochemical Properties

M.Wt 494.3174
Formula C22H12BrN3O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: 23.5 mg/mL

Chemical Name/SMILES

1H-Isoindole-1,3(2H)-dione, 5-[5-[[(5Z)-3-(4-bromophenyl)-2-imino-4-oxo-5-thiazolidinylidene]methyl]-2-furanyl]-

References

1. Wang G, et al. Nat Chem Biol. 2013 Feb;9(2):84-9.

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