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Bis-T-23

Chemical Structure : Bis-T-23

CAS No.: 171674-76-3

Bis-T-23 (Ryngo 1-23)

Catalog No.: PC-63280Not For Human Use, Lab Use Only.

Bis-T-23 is a small molecule that stimulates actin-dependent dynamin oligomerization and promotes dynamin GTPase activity, increases actin polymerization in injured podocytes.

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    Biological Activity

    Bis-T-23 (Ryngo 1-23) is a small molecule that stimulates actin-dependent dynamin oligomerization and promotes dynamin GTPase activity, increases actin polymerization in injured podocytes.
    Bis-T-23 ameliorates or prevents proteinuria and diminishes mesangial matrix expansion in diverse genetic and chronic models of glomerular disease in rodents.
    Bis-T-23 improves renal health in diverse models of both transient kidney disease and CKD.

    Physicochemical Properties

    M.Wt 480.433
    Formula C23H20N4O8
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (2E,2'E)-N,N'-1,3-Propanediylbis[2-cyano-3-(3,4,5-trihydroxyphenyl)-2-propenamide]

    References

    1. Schiffer M, et al. Nat Med. 2015 Jun;21(6):601-9.

    2. Del Nogal-Avila M, et al. Am J Physiol Renal Physiol. 2016 Jul 1;311(1):F63-5.

    3. Gu C, et al. J Am Soc Nephrol. 2017 Feb;28(2):446-451.

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