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Bischof-5

Chemical Structure : Bischof-5

CAS No.: 1446200-49-2

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Bischof-5 (Bischof 5;Bischof5;CK1δ inhibitor 5)

Catalog No.: PC-60581Not For Human Use, Lab Use Only.

Bischof-5 (CK1δ inhibitor 5) is a potent, specific casein kinase 1δ (CK1δ) inhibitor with IC50 of 40 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Bischof-5 (CK1δ inhibitor 5) is a potent, specific casein kinase 1δ (CK1δ) inhibitor with IC50 of 40 nM.
    Bischof-5 exhibits 5-fold higher affinity towards CK1δ than to CK1ε (IC50=199 nM), demonstrates good selectivity against a panel of over 442 kinases.
    Bischof-5 inhibits proliferation of tumor cell lines in a dose and cell line specific manner.

    Physicochemical Properties

    M.Wt 515.39
    Formula C20H11F6N5O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(2-(trifluoromethoxy)benzamido)-N-(6-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)thiazole-4-carboxamide

    References

    1. Bischof J, et al. Amino Acids. 2012 Oct;43(4):1577-91.

    2. Bibian M, et al. Bioorg Med Chem Lett. 2013 Aug 1;23(15):4374-80.

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