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Bitopertin R enantiomer

Chemical Structure : Bitopertin R enantiomer

CAS No.: 845614-12-2

Bitopertin R enantiomer (RG-1678 R enantiomer;RO-4917838 R enantiomer)

Catalog No.: PC-42707Not For Human Use, Lab Use Only.

A potent and selective GlyT1 inhibitor with EC50 of 54 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A potent and selective GlyT1 inhibitor with EC50 of 54 nM; no activity for GlyT2, hERG, CYP450 enzymes above 10 uM; the R enantiomer of RG-1678.

Schizophrenia

Phase 3 Clinical

Physicochemical Properties

M.Wt 543.455
Formula C21H20F7N3O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Methanone, [4-[3-fluoro-5-(trifluoromethyl)-2-pyridinyl]-1-piperazinyl][5-(methylsulfonyl)-2-[(1R)-2,2,2-trifluoro-1-methylethoxy]phenyl]-

References

1. Pinard E, et al. J Med Chem. 2010 Jun 24;53(12):4603-14.

2. Alberati D, et al. Neuropharmacology. 2012 Feb;62(2):1152-61

3. Martin-Facklam M, et al. Neuropsychopharmacology. 2013 Feb;38(3):504-12.

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