Catalog No.: PC-73174Not For Human Use, Lab Use Only.
Bivalirudin (Bivalitroban) is a potent, selective inhibitor of α- and ζ-thrombin (Ki= 2.56 and 1.84 nM, respectively), exhibits high fibrinogen-clotting activities.
Bivalirudin (Bivalitroban) is a potent, selective inhibitor of α- and ζ-thrombin (Ki= 2.56 and 1.84 nM, respectively), exhibits high fibrinogen-clotting activities. Bivalirudin displays >1,000-fold selecivity for α- and ζ-thrombin over trypsin and γ-thrombin. Bivalirudin inhibits α-thrombin-stimulated activation of the clotting factors Factor X, Factor V, and prothrombin in contact-activated plasma at 0.1 uM. Bivalirudin (0.5-1.5 mg/kg, i.v.) reduces platelet deposition in a rat carotid endarterectomy model in a dose-dependent manner.
Physicochemical Properties
M.Wt
2180.3
Formula
C98H138N24O33
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Month
Shipping
Solubility
Chemical Name/SMILES
References
1. Witting, J.I., et al. Biochem J. 283(Pt 3), 737-743 (1992).
2. Ofosu, F.A., et al. Biochem J. 283(Pt 3), 893-897 (1992).
3. Hamelink, J.K., et al. J. Vasc. Surg. 21(3), 492-498 (1995).
