Chemical Structure : Blixeprodil
CAS No.:
2881017-49-6
Blixeprodil
(GM-1020, GM1020)
Catalog No.: PC-24115Not For Human Use, Lab Use Only.
Blixeprodil (GM-1020) is a selective NMDA receptor (NMDAR) antagonist, displaces [3H]MK-801 binding to NMDAR in rat cortical tissue with Ki of 3.25 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Blixeprodil (GM-1020) is a selective NMDA receptor (NMDAR) antagonist, displaces [3H]MK-801 binding to NMDAR in rat cortical tissue with Ki of 3.25 uM.
GM-1020 shows no binding affinity for AMPA, melanocortin 4, and α4β2 nicotinic acetylcholine receptors, and no agonist activity at the 5-HT1B receptor.
GM-1020 showed functional inhibition of NMDAR-mediated currents in NR2A- and NR2B-containing receptors, with IC50 values of 3.70 µM and 4.16 µM, respectively.
GM-1020 showed functional inhibition of NR1/2A-NMDAR-mediated currents with IC50 of 1.192 µM in HEK cells.
GM-1020 shows rapid and robust antidepressant-like effects.
Physicochemical Properties
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M.Wt
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221.28
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Formula
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C13H16FNO
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(2R)-2-(4-fluorophenyl)-2-(methylamino)cyclohexan-1-one
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References
1. Klein AK, et al. Neuropsychopharmacology. 2024 May;49(6):905-914.
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