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Boceprevir

Chemical Structure : Boceprevir

CAS No.: 394730-60-0

Boceprevir (EBP520, SCH503034, EBP-520, SCH-503034)

Catalog No.: PC-42477Not For Human Use, Lab Use Only.

Boceprevir (EBP520, SCH503034) is a potent, selective, orally bioavailable HCV NS3 protease with Ki of 14 nM, EC90 of 350 nM in cell replicon assays.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Boceprevir (EBP520, SCH503034) is a potent, selective, orally bioavailable HCV NS3 protease with Ki of 14 nM, EC90 of 350 nM in cell replicon assays.
Boceprevir  displays >2000-fold selectivity over human neutrophil elastase (HNE).

Physicochemical Properties

M.Wt 519.6767
Formula C27H45N5O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 10 mg/mL

Chemical Name/SMILES

3-Azabicyclo[3.1.0]hexane-2-carboxamide, N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[(2S)-2-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl-, (1R,2S,5S)-

References

1. Venkatraman S, et al. J Med Chem. 2006 Oct 5;49(20):6074-86.

2. Sarrazin C, et al. Gastroenterology. 2007 Apr;132(4):1270-8.

3. Flint M, et al. Antimicrob Agents Chemother. 2009 Feb;53(2):401-11.

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