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Chemical Structure : Box5
CAS No.: 1206604-29-6
Catalog No.: PC-35020Not For Human Use, Lab Use Only.
Box5 is a Wnt5a-derived N-butyloxycarbonyl hexapeptide (t-Boc-Met-Asp-Gly-Cys-Glu-Leu), acts as an Wnt5a antagonist.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $148 | In stock | |
| 10 mg | $228 | In stock | |
| 25 mg | $378 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Box5 is a Wnt5a-derived N-butyloxycarbonyl hexapeptide (t-Boc-Met-Asp-Gly-Cys-Glu-Leu), acts as an Wnt5a antagonist.
Box5 abolishes exogenous Wnt5a stimulation of A2058 cells increased adhesion, migration and invasion, all crucial components of tumor metastasis.
Box5 also inhibits the basal migration and invasion of Wnt5a-expressing HTB63 melanoma cells, antagonizes the effects of Wnt5a on melanoma cell migration and invasion by directly inhibiting Wnt5a-induced PKC and Ca(2+) signaling.
| M.Wt | 766.88 | |
| Formula | C30H50N6O13S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-[(1,1-Dimethylethoxy)carbonyl]-L-methionyl-L-alpha-aspartylglycyl-L-cysteinyl-L-alpha-glutamyl-L-leucine |
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1. Jenei V, et al. Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19473-8.
2. Linnskog R, et al. Oncotarget. 2016 Jun 21;7(25):37790-37802.
3. Yuan S, et al. J Neuroimmune Pharmacol. 2012 Dec;7(4):904-13.
4. Ackers I, et al. Cardiovasc Pathol. 2018 May-Jun;34:1-8.
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