Brevilin A

Chemical Structure : Brevilin A

CAS No.: 16503-32-5

Catalog No.: PC-25382Not For Human Use, Lab Use Only.

Packing	Price	Stock
5 mg	$138	In stock
10 mg	$218	In stock
25 mg	$378	In stock
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Biological Activity

Brevilin A is an orally active STAT3/JAK inhibitor with IC50 of 10.6 uM (STAT3), exerts potent anti-inflammatory, antitumor, immunosuppressive, and anti-liver fibrosis effects, also reduces protein levels of LRRC15 in RA fibroblast-like synoviocytes (RA-FLSs).
Brevilin A is reported to regulate the SIRT1/Nrf2/GPX4 signaling pathway to inhibit the production of MMP1 and MMP3 and alleviate joint damage in mice.
Brevilin A effectively alleviates LPS-induced lung damage, inflammatory infiltration, and the production of proinflammatory cytokines in LPS-induced acute lung injury.
Brevilin A significantly reduced the protein levels of LRRC15 in TNF-α-induced RA fibroblast-like synoviocytes (RA-FLSs).
Brevilin A significantly inhibited STAT3 phosphorylation without affecting total STAT3 protein levels
Brevilin A ameliorates arthritis symptoms in CIA rats.

Physicochemical Properties

M.Wt	346.42
Formula	C20H26O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3S,3aR,4S,4aR,7aR,8R,9aR)-3,4a,8-Trimethyl-2,5-dioxo-2,3,3a,4,4a,5,7a,8,9,9a-decahydroazuleno[6,5-b]furan-4-yl (Z)-2-methylbut-2-enoate

References

1. Chen X, et al. PLoS One. 2013 May 21;8(5):e63697.

2. Qiao Z, et al. Arthritis Res Ther. 2025 Aug 20;27(1):167.

Brevilin A

Biological Activity

Physicochemical Properties

References

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