Chemical Structure : Bupivacaine
CAS No.:
38396-39-3
Bupivacaine
Catalog No.: PC-28479Not For Human Use, Lab Use Only.
Bupivacaine is a long-acting aminoamide local anesthetic agent and N-methyl-D-aspartate (NMDA) receptor blocker, blocks sodium, L-calcium, and potassium channels, potently blocks SCN5A channels (Nav1.5 sodium channel alpha subunit) with IC50 of 69.5 uM, inhibits human neuronal Kv3 channels in SH-SY5Y human neuroblastoma cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Bupivacaine is a long-acting aminoamide local anesthetic agent and N-methyl-D-aspartate (NMDA) receptor blocker, blocks sodium, L-calcium, and potassium channels, potently blocks SCN5A channels (Nav1.5 sodium channel alpha subunit) with IC50 of 69.5 uM, inhibits human neuronal Kv3 channels in SH-SY5Y human neuroblastoma cells.
Physicochemical Properties
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M.Wt
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288.44
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Formula
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C18H28N2O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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1-Butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
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References
1. Nadrowitz F, et al. Anesth Analg. 2013 Nov;117(5):1101-8.
2. Martín P, et al. Channels (Austin). 2012 May-Jun;6(3):174-80.
3. Arias C, et al. Anesthesiology. 2007 Oct;107(4):641-51.
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