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C-1311 dihydrochloride

Chemical Structure : C-1311 dihydrochloride

CAS No.: 138154-55-9

C-1311 dihydrochloride (XLS-002;Symadex;Imidacrine;Imidazoacridone)

Catalog No.: PC-61465Not For Human Use, Lab Use Only.

C-1311 dihydrochloride (Imidacrine, Imidazoacridone) is an imidazoacridinone analogue with potent in vivo antitumour activity, inhibits the catalytic activity of Topoisomerase II.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    C-1311 dihydrochloride (Imidacrine, Imidazoacridone) is an imidazoacridinone analogue with potent in vivo antitumour activity, inhibits the catalytic activity of Topoisomerase II.
    C-1311 induces p53-dependent senescence or p53-independent apoptosis and sensitizes cancer cells to radiation, also induces autophagy in a non-p53-dependent manner.
    C-1311 effectively improves the radiosensitivity of a panel of cancer cell lines.

    Physicochemical Properties

    M.Wt 441.35
    Formula C20H26Cl2N4O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    5-((2-(diethylamino)ethyl)amino)-8-hydroxy-6H-imidazo[4,5,1-de]acridin-6-one dihydrochloride

    References

    1. Lamb J, et al. Br J Cancer. 1996 Nov;74(9):1359-68.

    2. Skladanowski A, et al. Mol Pharmacol. 1996 May;49(5):772-80.

    3. Skwarska A, et la. Oncotarget. 2017 May 9;8(19):31187-31198.

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