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Chemical Structure : C-1311 dihydrochloride
Catalog No.: PC-61465Not For Human Use, Lab Use Only.
C-1311 dihydrochloride (Imidacrine, Imidazoacridone) is an imidazoacridinone analogue with potent in vivo antitumour activity, inhibits the catalytic activity of Topoisomerase II.
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C-1311 dihydrochloride (Imidacrine, Imidazoacridone) is an imidazoacridinone analogue with potent in vivo antitumour activity, inhibits the catalytic activity of Topoisomerase II.
C-1311 induces p53-dependent senescence or p53-independent apoptosis and sensitizes cancer cells to radiation, also induces autophagy in a non-p53-dependent manner.
C-1311 effectively improves the radiosensitivity of a panel of cancer cell lines.
| M.Wt | 441.35 | |
| Formula | C20H26Cl2N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lamb J, et al. Br J Cancer. 1996 Nov;74(9):1359-68.
2. Skladanowski A, et al. Mol Pharmacol. 1996 May;49(5):772-80.
3. Skwarska A, et la. Oncotarget. 2017 May 9;8(19):31187-31198.
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