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Chemical Structure : C-DIM5
CAS No.: 33985-68-1
Catalog No.: PC-63275Not For Human Use, Lab Use Only.
C-DIM5 (DIM-C-pPhOCH3) is an orally active diindolylmethane (C-DIM) compound that displays anti-inflammatory and neuroprotective efficacy in vitro and in vivo, also is an agonist of the orphan nuclear receptor Nur77.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $188 | In stock | |
| 50 mg | $288 | In stock | |
| 100 mg | $428 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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C-DIM5 (DIM-C-pPhOCH3) is an orally active diindolylmethane (C-DIM) compound that displays anti-inflammatory and neuroprotective efficacy in vitro and in vivo, also is an agonist of the orphan nuclear receptor Nur77.
C-DIM5 protects against MPTP neurotoxicity and suppresses glial activation in mouse model of Parkinson's disease.
C-DIM5 decreases cell survival and induces cell death pathways, including TRAIL and PARP cleavage, inhibits tumor growth in vivo in mice bearing Panc-28 cell xenografts.
| M.Wt | 352.437 | |
| Formula | C24H20N2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
1,1-bis(3'-indolyl)-1-(p-methoxyphenyl)methane |
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1. De Miranda BR, et al. J Pharmacol Exp Ther. 2013 Apr;345(1):125-38.
2. De Miranda BR, et al. Toxicol Sci. 2015 Feb;143(2):360-73.
3. Chintharlapalli S, et al. J Biol Chem. 2005 Jul 1;280(26):24903-14.
4. Lee SO, et al. Mol Cancer Res. 2009 Jul;7(7):1169-78.
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