Catalog No.: PC-63275Not For Human Use, Lab Use Only.
C-DIM5 (DIM-C-pPhOCH3) is an orally active diindolylmethane (C-DIM) compound that displays anti-inflammatory and neuroprotective efficacy in vitro and in vivo, also is an agonist of the orphan nuclear receptor Nur77.
C-DIM5 (DIM-C-pPhOCH3) is an orally active diindolylmethane (C-DIM) compound that displays anti-inflammatory and neuroprotective efficacy in vitro and in vivo, also is an agonist of the orphan nuclear receptor Nur77.
C-DIM5 protects against MPTP neurotoxicity and suppresses glial activation in mouse model of Parkinson's disease.
C-DIM5 decreases cell survival and induces cell death pathways, including TRAIL and PARP cleavage, inhibits tumor growth in vivo in mice bearing Panc-28 cell xenografts.
Physicochemical Properties
M.Wt
352.437
Formula
C24H20N2O
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
1,1-bis(3'-indolyl)-1-(p-methoxyphenyl)methane
References
1. De Miranda BR, et al. J Pharmacol Exp Ther. 2013 Apr;345(1):125-38.
2. De Miranda BR, et al. Toxicol Sci. 2015 Feb;143(2):360-73.
