Catalog No.: PC-49461Not For Human Use, Lab Use Only.
C101248 is the first selective small-molecule inhibitor of tandem pore domain halothane-inhibited K+ channel 1 (THIK-1) with IC50 of 50 nM for both mouse and human THIK-1.
C101248 is the first selective small-molecule inhibitor of tandem pore domain halothane-inhibited K+ channel 1 (THIK-1) with IC50 of 50 nM for both mouse and human THIK-1.
C101248 is selective for THIK-1 and is inactive against K2P family members TREK-1 and TWIK-2, and Kv2.1.
C101248 potently blocked both tonic and ATP-evoked THIK-1 K+ currents in whole-cell patch-clamp recordings of microglia from mouse hippocampal slices.
C101248 had no effect on other constitutively active resting conductance in slices from THIK-1-depleted mice.
C101248 attenuated the NLRP3-dependent release of IL-1β from microglia.
