Chemical Structure : C28
CAS No.:
C28
(IKs activator C28)
Catalog No.: PC-23263Not For Human Use, Lab Use Only.
C28 is a specific small molecule activator of cardiac potassium ion channel IKs (KCNQ1+KCNE1), causes change of V1/2 of G-V relations with EC50 of 7.6 uM, interacts with the KCNQ1 voltage-sensing domain (VSD), and shifts voltage dependence of VSD activation to more negative voltages.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
C28 is a specific small molecule activator of cardiac potassium ion channel IKs (KCNQ1+KCNE1), causes change of V1/2 of G-V relations with EC50 of 7.6 uM, interacts with the KCNQ1 voltage-sensing domain (VSD), and shifts voltage dependence of VSD activation to more negative voltages.
C28 specifically shifted IKs VSD activation in ventricle to more negative voltages and reversed the drug-induced lengthening of action potential duration (APD).
C28 prevent or reverse the drug-induced APD prolongation back to normal while having a minimal effect on the control APD at the same concentration in healthy cardiac myocytes.
C28 also boosts the cAMP effects of KCNQ1.
Physicochemical Properties
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M.Wt
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416.38
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Formula
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C20H13N2NaO5S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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