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Chemical Structure : C28
Catalog No.: PC-23263Not For Human Use, Lab Use Only.
C28 is a specific small molecule activator of cardiac potassium ion channel IKs (KCNQ1+KCNE1), causes change of V1/2 of G-V relations with EC50 of 7.6 uM, interacts with the KCNQ1 voltage-sensing domain (VSD), and shifts voltage dependence of VSD activation to more negative voltages.
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C28 is a specific small molecule activator of cardiac potassium ion channel IKs (KCNQ1+KCNE1), causes change of V1/2 of G-V relations with EC50 of 7.6 uM, interacts with the KCNQ1 voltage-sensing domain (VSD), and shifts voltage dependence of VSD activation to more negative voltages.
C28 specifically shifted IKs VSD activation in ventricle to more negative voltages and reversed the drug-induced lengthening of action potential duration (APD).
C28 prevent or reverse the drug-induced APD prolongation back to normal while having a minimal effect on the control APD at the same concentration in healthy cardiac myocytes.
C28 also boosts the cAMP effects of KCNQ1.
| M.Wt | 416.38 | |
| Formula | C20H13N2NaO5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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