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C2BA-4

Chemical Structure : C2BA-4

CAS No.: 712333-04-5

C2BA-4 (C2BA 4)

Catalog No.: PC-60008Not For Human Use, Lab Use Only.

C2BA-4 is a potent, specific human Pregnane X receptor (hPXR) activator with EC50 of 49 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    C2BA-4 is a potent, specific human Pregnane X receptor (hPXR) activator with EC50 of 49 nM.
    C2BA-4 activates PXR specifically and more potently than SR12813, induces mRNA expression of hPXR target genes, such as CYPP450 3A4 and 2B6 in primary human hepatocytes.
    C2BA-4 also induces hPXR-mediated in vivo luciferase expression in HGPXR stable bioluminescent cells implanted in mice.

    Physicochemical Properties

    M.Wt 425.931
    Formula C22H20ClN3O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    1-(2-Chlorophenyl)-N-[1-(1-phenylethyl)-1H-benzimidazol-5-yl]methanesulfonamide

    References

    1. Lemaire G, et al. Mol Pharmacol. 2007 Sep;72(3):572-81.

    2. Benod C, et al. Bioorg Med Chem. 2008 Apr 1;16(7):3537-49.

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