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Chemical Structure : C2BA-4
Catalog No.: PC-60008Not For Human Use, Lab Use Only.
C2BA-4 is a potent, specific human Pregnane X receptor (hPXR) activator with EC50 of 49 nM.
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C2BA-4 is a potent, specific human Pregnane X receptor (hPXR) activator with EC50 of 49 nM.
C2BA-4 activates PXR specifically and more potently than SR12813, induces mRNA expression of hPXR target genes, such as CYPP450 3A4 and 2B6 in primary human hepatocytes.
C2BA-4 also induces hPXR-mediated in vivo luciferase expression in HGPXR stable bioluminescent cells implanted in mice.
| M.Wt | 425.931 | |
| Formula | C22H20ClN3O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lemaire G, et al. Mol Pharmacol. 2007 Sep;72(3):572-81.
2. Benod C, et al. Bioorg Med Chem. 2008 Apr 1;16(7):3537-49.
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