Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
    English |     Chinese

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-Nuclear Receptor/Transcription Factor-Pregnane X Receptor (PXR)-C2BA-4
C2BA-4

Chemical Structure : C2BA-4

CAS No.: 712333-04-5

Add to Favorites

C2BA-4 (C2BA 4)

Catalog No.: PC-60008Not For Human Use, Lab Use Only.

C2BA-4 is a potent, specific human Pregnane X receptor (hPXR) activator with EC50 of 49 nM.

Packing Price Stock Quantity
25 mg Get quote
50 mg Get quote
100 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

Welcome credit card payment!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    C2BA-4 is a potent, specific human Pregnane X receptor (hPXR) activator with EC50 of 49 nM.
    C2BA-4 activates PXR specifically and more potently than SR12813, induces mRNA expression of hPXR target genes, such as CYPP450 3A4 and 2B6 in primary human hepatocytes.
    C2BA-4 also induces hPXR-mediated in vivo luciferase expression in HGPXR stable bioluminescent cells implanted in mice.

    Physicochemical Properties

    M.Wt 425.931
    Formula C22H20ClN3O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-(2-Chlorophenyl)-N-[1-(1-phenylethyl)-1H-benzimidazol-5-yl]methanesulfonamide

    References

    1. Lemaire G, et al. Mol Pharmacol. 2007 Sep;72(3):572-81.

    2. Benod C, et al. Bioorg Med Chem. 2008 Apr 1;16(7):3537-49.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: