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C381

Chemical Structure : C381

CAS No.: 1629138-41-5

C381 (SRI011381, SRI-011381)

Catalog No.: PC-72935Not For Human Use, Lab Use Only.

C381 (SRI011381) is a first-in-class, CNS bioactive compound capable of restoring lysosomal function with prominent antiinflammatory and neuroprotective activities.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

C381 (SRI011381) is a first-in-class, CNS bioactive compound capable of restoring lysosomal function with prominent antiinflammatory and neuroprotective activities.
C381 physically targets the lysosome, promotes lysosomal acidification, increases breakdown of lysosomal cargo, and improves lysosome resilience to damage.
C381 has the potential both as a therapeutic and as a research compound to better understand lysosomal contributions to disease progression.
C381 is an orally bioavailable and brain penetrant Smad activator found in phenotypic screen.

Physicochemical Properties

M.Wt 329.488
Formula C20H31N3O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-benzyl-3-cyclohexyl-1-(piperidin-4-ylmethyl)urea

References

1. Ryan T Vest, et al. Proc Natl Acad Sci U S A. 2022 Mar 15;119(11):e2121609119.

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