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Chemical Structure : C5-benzyl SAHA
Catalog No.: PC-62846Not For Human Use, Lab Use Only.
C5-benzyl SAHA is a C5-modified SAHA analog that displays dual selectivity to HDAC6 (IC50=0.27 uM) and HDAC8 (IC50=0.38 uM) over HDAC 1, 2, and 3 (IC50=2.9-5.8 uM).
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C5-benzyl SAHA is a C5-modified SAHA analog that displays dual selectivity to HDAC6 (IC50=0.27 uM) and HDAC8 (IC50=0.38 uM) over HDAC 1, 2, and 3 (IC50=2.9-5.8 uM).
C5-benzyl SAHA dose dependently and selectively increases in levels of acetyl-α-tubulin in U937 leukemia cells.
| M.Wt | 354.45 | |
| Formula | C21H26N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Negmeldin AT, et al. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3254-3258.
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