Catalog No.: PC-38719Not For Human Use, Lab Use Only.
C644-0303 is a novel Wnt/β-catenin signaling inhibitor (IC50=4.2 uM) with antitumor efficacy, inhibits both constitutive and ligand activated Wnt signals and its downstream gene expression.
C644-0303 is a novel Wnt/β-catenin signaling inhibitor (IC50=4.2 uM) with antitumor efficacy, inhibits both constitutive and ligand activated Wnt signals and its downstream gene expression.
C644‐0303 potently inhibits the cell growth of HCT‐116 (IC50, 17.69 uM), but not a human normal colon epithelial cell line CCD‐841CoN (IC50>50 uM).
C644‐0303 efficiently inhibits proliferation of Wnt‐dependent cancer cell lines (IC50, 10‐25 uM) with little effect on the viability of Wnt‐independent cancer cell lines (IC50>100 uM).
C644‐0303 inhibits β‐catenin activity and its downstream target gene expression, causes cell cycle arrest, induces apoptosis, and inhibits cancer cell migration.
C644‐0303 potently inhibits TCF/LEF activity and modulates β‐catenin activity associated phosphorylation in HCT‐116 cells.
C644‐0303 inhibits the spheroidization and growth of CRC cells both in vitro and in vivo.
