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Chemical Structure : C644-0303
Catalog No.: PC-38719Not For Human Use, Lab Use Only.
C644-0303 is a novel Wnt/β-catenin signaling inhibitor (IC50=4.2 uM) with antitumor efficacy, inhibits both constitutive and ligand activated Wnt signals and its downstream gene expression.
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C644-0303 is a novel Wnt/β-catenin signaling inhibitor (IC50=4.2 uM) with antitumor efficacy, inhibits both constitutive and ligand activated Wnt signals and its downstream gene expression.
C644‐0303 potently inhibits the cell growth of HCT‐116 (IC50, 17.69 uM), but not a human normal colon epithelial cell line CCD‐841CoN (IC50>50 uM).
C644‐0303 efficiently inhibits proliferation of Wnt‐dependent cancer cell lines (IC50, 10‐25 uM) with little effect on the viability of Wnt‐independent cancer cell lines (IC50>100 uM).
C644‐0303 inhibits β‐catenin activity and its downstream target gene expression, causes cell cycle arrest, induces apoptosis, and inhibits cancer cell migration.
C644‐0303 potently inhibits TCF/LEF activity and modulates β‐catenin activity associated phosphorylation in HCT‐116 cells.
C644‐0303 inhibits the spheroidization and growth of CRC cells both in vitro and in vivo.
| M.Wt | 466.589 | |
| Formula | C25H23FN2O2S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yu Yan, et al. Cancer Sci. 2021 Nov;112(11):4722-4735.
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