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Chemical Structure : C67399
Catalog No.: PC-73352Not For Human Use, Lab Use Only.
C67399 is a small molecule that blocks the integrin β1 binding site of TLN1, reduces the malignant behaviours of TNBC in vitro (MDA-MB-231 cell, IC50=2.0 uM).
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C67399 is a small molecule that blocks the integrin β1 binding site of TLN1, reduces the malignant behaviours of TNBC in vitro (MDA-MB-231 cell, IC50=2.0 uM).
C67399 treatment significantly reduced the viability of BT549 cells.
C67399 (2 uM) significantly reduced the expression of integrin β1, AKT, FAK, and phosphorylated FAK in MDA-MB-231 cells, while did not affect the expression of integrin β3.
C67399 inhibited the binding of TLN1 to integrin β1 in MDA-MB-231 cells.
C67399 (1.75 mg/kg) inhibited tumour growth and metastasis of MDA-MB-231 cells in mice, without causing obvious structural toxic changes.
| M.Wt | 584.797 | |
| Formula | C38H48O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yixiao Zhang, et al. Elife. 2022 Mar 14;11:e68481.
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