CA-074 | Cathepsin B inhibitor | Probechem Biochemicals

Chemical Structure : CA-074

CAS No.: 134448-10-5

CA-074 (CA074)

Catalog No.: PC-21936Not For Human Use, Lab Use Only.

CA-074 is a potent, specific and cell-permeable inhibitor of cathepsin B with Ki of 2-5 nM.

Packing	Price	Stock
5 mg	$258	In stock
10 mg	$388	In stock
25 mg	$598	In stock
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Biological Activity

CA-074 is a potent, specific and cell-permeable inhibitor of cathepsin B with Ki of 2-5 nM.
CA-074 displays 10,000-30,000 times greater inhibitory activity than cathepsin H and L.
CA-074 improves memory and reduces beta-amyloid in transgenic Alzheimer disease mice.

Physicochemical Properties

M.Wt	383.45
Formula	C18H29N3O6
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1-((2S,3S)-3-Methyl-2-((2S,3S)-3-(propylcarbamoyl)oxirane-2-carboxamido)pentanoyl)pyrrolidine-2-carboxylic acid

References

1. Towatari T, et al. FEBS Lett. 1991 Mar 25;280(2):311-5.

2. Montaser M, et al. Biol Chem. 2002 Jul-Aug;383(7-8):1305-8.

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CA-074 (CA074)

Biological Activity

Physicochemical Properties

References

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