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CA-074 methyl ester

Chemical Structure : CA-074 methyl ester

CAS No.: 147859-80-1

CA-074 methyl ester (CA074 methyl ester;CA-074Me)

Catalog No.: PC-42108Not For Human Use, Lab Use Only.

CA-074 methyl ester is a potent, specific and cell-permeable inhibitor of cathepsin B with Ki of 2-5 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CA-074 methyl ester is a potent, specific and cell-permeable inhibitor of cathepsin B with Ki of 2-5 nM.
CA-074 methyl ester displays 10,000-30,000 times greater inhibitory activity than cathepsin H and L.
CA-074 methyl ester improves memory and reduces beta-amyloid in transgenic Alzheimer disease mice.

Physicochemical Properties

M.Wt 397.4659
Formula C19H31N3O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

H2O: 26.66 mg/mL (Need warming)

Chemical Name/SMILES

L-Proline, N-[[(2S,3S)-3-[(propylamino)carbonyl]-2-oxiranyl]carbonyl]-L-isoleucyl-, methyl ester

References

1. Towatari T, et al. FEBS Lett. 1991 Mar 25;280(2):311-5.

2. Hook VY, et al. J Biol Chem. 2008 Mar 21;283(12):7745-53.

3. Montaser M, et al. Biol Chem. 2002 Jul-Aug;383(7-8):1305-8.

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