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Chemical Structure : CA-170
CAS No.: 1673534-76-3
Catalog No.: PC-72654Not For Human Use, Lab Use Only.
CA-170 (CA170) is a first-in-class, orally available, tripeptide small-molecule dual antagonist of VISTA/PD-L1, important negative checkpoint regulators of immune activation.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $248 | In stock | |
| 10 mg | $378 | In stock | |
| 25 mg | $628 | In stock | |
| 100 mg | $1380 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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CA-170 (CA170) is a first-in-class, orally available, tripeptide small-molecule dual antagonist of VISTA/PD-L1, important negative checkpoint regulators of immune activation.
CA-170 demonstrated dose-dependent enhancement in the proliferation of PD-L1, PD-L2, and VISTA-inhibited T lymphocytes, and exhibited antitumor effects similar to those of antibodies, including tumor shrinkages and prolonged stable disease without adverse effects.
CA170 has excellent oral bioavailability, a relatively short half-life, and it can dose-dependently enhance the proliferation of T lymphocytes due to its ability to inhibit VISTA.
In syngeneic murine tumor models, the antitumor effects of CA170 were similar to VISTA-blocking antibody.
CA170 was well tolerated in phase I clinical trials and is undergoing phase II clinical trials for lung cancer, head and neck/oral cavity cancer, MSI-H positive cancers, and Hodgkin lymphoma.
| M.Wt | 360.33 | |
| Formula | C12H20N6O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
50 mM in DMSO (18.1 mg/mL) |
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| Chemical Name/SMILES |
(((S)-3-amino-1-(3-((S)-1-amino-2-hydroxyethyl)-1,2,4-oxadiazol-5-yl)-3-oxopropyl)carbamoyl)-L-allothreonine |
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1. Musielak B, et al. Molecules. 2019 Aug 1;24(15):2804.
2. Sasikumar PG, et al. Commun Biol. 2021 Jun 8;4(1):699.
3. Li TT, et al. BMC Immunol. 2021 Aug 11;22(1):55.
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