CAIS-1 | Chromosome congression inhibitor

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Chemical Structure : CAIS-1

CAIS-1 (Chromosome alignment inhibitor featuring sulfonamide-1)

Catalog No.: PC-23659Not For Human Use, Lab Use Only.

CAIS-1 is a small molecule inhibitor of chromosome congression, inhibits chromosome congression at low concentrations and spindle microtubule formation at high concentrations.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

CAIS-1 is a small molecule inhibitor of chromosome congression, inhibits chromosome congression at low concentrations and spindle microtubule formation at high concentrations.
CAIS-1 effectively induces cell cycle arrest during mitosis in a concentration-dependent manner (IC50=4.6 uM) in HeLa cells.
CAIS-1 induces apoptotic cell death after prolonged mitotic arrest.
CAIS-1 inhibits tubulin polymerization and binding to colchicine but does not have a significant inhibitory effect on mitotic kinases.

Physicochemical Properties

M.Wt	292.35
Formula	C14H16N2O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-Amino-4-methoxy-N-methyl-N-phenylbenzenesulfonamide

References

1. Sawada JI, et al. Biochem Pharmacol. 2024 Dec 17:116718.

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CAIS-1 (Chromosome alignment inhibitor featuring sulfonamide-1)

Biological Activity

Physicochemical Properties

References

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