Chemical Structure : CAIS-2
CAS No.:
924136-73-2
CAIS-2
(Chromosome alignment inhibitor featuring sulfonamide-2)
Catalog No.: PC-23660Not For Human Use, Lab Use Only.
CAIS-2 is a specific mitotic inhibitor, selectively inhibits chromosome congression without affecting spindle microtubules.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CAIS-2 is a specific mitotic inhibitor, selectively inhibits chromosome congression without affecting spindle microtubules.
CAIS-2 exhibits concentration-dependent antimitotic and antiproliferative activities, with IC50 values of 7.2 μM and 3.5 μM in HeLa cells, respectively.
CAIS-2 does not inhibit spindle microtubule formation even at concentrations as high as 128 μM in HeLa cells.
CAIS-2 shows no significant effect on tubulin polymerization or tubulin binding to colchicine, even at 80 μM, in contrast to CAIS-1.
CAIS-2 shows no inhibitory activity against the ATPase activity of the CENP-E motor domain in vitro.
CAIS-2 inhibits HeLa cell proliferation.
Physicochemical Properties
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M.Wt
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334.39
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Formula
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C16H18N2O4S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-[2-Methoxy-5-[(methylphenylamino)sulfonyl]phenyl]acetamide
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References
1. Sawada JI, et al. Biochem Pharmacol. 2024 Dec 17:116718.
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