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CAIX inhibitor S4

Chemical Structure : CAIX inhibitor S4

CAS No.: 1330061-67-0

CAIX inhibitor S4 (CA9 inhibitor S4)

Catalog No.: PC-26516Not For Human Use, Lab Use Only.

CAIX inhibitor S4 is a potent, specific CA IX/XII inhibitor with Ki of 7 nM and 2 nM for human CA IX (CA9) and CA XII (CA12) respectively, much weakly inhibits CA II and CA I, inhibits lung metastasis in orthotopic MDA-MB-231 mouse model.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CAIX inhibitor S4 is a potent, specific CA IX/XII inhibitor with Ki of 7 nM and 2 nM for human CA IX (CA9) and CA XII (CA12) respectively, much weakly inhibits CA II and CA I, inhibits lung metastasis in orthotopic MDA-MB-231 mouse model.

Physicochemical Properties

M.Wt 335.38
Formula C15H17N3O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-(3-(3,5-Dimethylphenyl)ureido)phenyl sulfamate

References

1. Gieling RG, et, al. J Med Chem. 2012 Jun 14;55(11):5591-600.

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