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CAM4712

Chemical Structure : CAM4712

CAS No.: 2771505-45-2

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CAM4712 (CAM 4712, CAM-4712)

Catalog No.: PC-35185Not For Human Use, Lab Use Only.

CAM4712 (CAM-4712) is a potent and selective CK2alpha (CK2α) inhibitor with IC50 of 7 uM, exhibits cell growth inhibition in HCT116 cell line with IC50 of 10 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CAM4712 (CAM-4712) is a potent and selective CK2alpha (CK2α) inhibitor with IC50 of 7 uM, exhibits cell growth inhibition in HCT116 cell line with IC50 of 10 uM.
    CAM4712 displays good selectivity against the 20 closely related CMGC kinases.
    CAM4712 inhibits CK2α dependent phosphorylation of Ser129 of Akt1 in cellular assays.
    CAM4712 has numerous advantages over the previously reported CAM4066.

    Physicochemical Properties

    M.Wt 424.37
    Formula C24H23Cl2N3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(1H-benzo[d]imidazol-2-yl)-N-((2,6-dichloro-2'-ethyl-[1,1'-biphenyl]-4-yl)methyl)ethan-1-amine

    References

    1. Iegre J, et al. Chem Sci. 2018 Feb 20;9(11):3041-3049.

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