Chemical Structure : CAPCA-1
CAS No.:
1370242-23-1
CAPCA-1
Catalog No.: PC-25193Not For Human Use, Lab Use Only.
CAPCA-1 (Cpmpound B) a highly potent cap-dependent endonuclease (CEN) inhibitor, shows broad-spectrum antiviral activity against bunyavirus including Lassa virus (LASV), lymphocytic choriomeningitis virus (LCMV), and Influenza viruses.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CAPCA-1 (Cpmpound B) a highly potent cap-dependent endonuclease (CEN) inhibitor, shows broad-spectrum antiviral activity against bunyavirus including Lassa virus (LASV), lymphocytic choriomeningitis virus (LCMV), and Influenza viruses.
CAPCA-1 inhibited LACV-induced CPE in a noncytotoxic range in a dose-dependent manner, with an EC50 value of 0.45 µM in CPE-based assays.
CAPCA-1 inhibits LACV-induced cell death at lower concentrations than the other CEN inhibitors.
CAPCA-1 reduced the LACV-induced CPE and viral growth in SH-SY5Y with EC50 of 0.69 uM.
CAPCA-1 disrupts the post-entry phase of LACV infection.
CAPCA-1 reduces the LACV burden and protects mice from lethal LACV infection.
CAPCA-1 is 100- to 1,000-fold more active in vitro than ribavirin against bunyaviruses, including Lassa virus, lymphocytic choriomeningitis virus (LCMV), and Junin virus.
Physicochemical Properties
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M.Wt
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459.50
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Formula
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C26H25N3O5
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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1-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-yl)-5-hydroxy-3-isopropyl-4,6-dioxo-2,3,4,6-tetrahydro-1H-pyrido[2,1-f][1,2,4]triazine-7-carboxylic acid
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References
1. Toba S, et al. Proc Natl Acad Sci U S A. 2022 Sep 6;119(36):e2206104119.
2. Konishi K, et al. Antimicrob Agents Chemother. 2025 Jul 23:e0018625.
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