CARD8 activator CQ31 | PEPD/XPNPEP1 inhibitor

Chemical Structure : CARD8 activator CQ31

CARD8 activator CQ31 (CQ31)

Catalog No.: PC-38334Not For Human Use, Lab Use Only.

CARD8 activator CQ31 is a small molecule that selectively activates CARD8, inhibits the M24B aminopeptidases prolidase (PEPD) and Xaa-Pro aminopeptidase 1 (XPNPEP1), leading to the accumulation of proline-containing peptides that inhibit DPP8/9 and thereby activate CARD8.

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Biological Activity

CARD8 activator CQ31 is a small molecule that selectively activates CARD8, inhibits the M24B aminopeptidases prolidase (PEPD) and Xaa-Pro aminopeptidase 1 (XPNPEP1), leading to the accumulation of proline-containing peptides that inhibit DPP8/9 and thereby activate CARD8.

Physicochemical Properties

M.Wt	272.345
Formula	C13H24N2O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl ((2S,3R)-3-amino-2-hydroxy-5-methylhexanoyl)-D-prolinate

References

1. Sahana D Rao, et al. Nat Chem Biol. 2022 Feb 14.

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CARD8 activator CQ31 (CQ31)

Biological Activity

Physicochemical Properties

References

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