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CARD8 activator CQ31

Chemical Structure : CARD8 activator CQ31

CAS No.: 441022-67-9

CARD8 activator CQ31 (CQ31)

Catalog No.: PC-38334Not For Human Use, Lab Use Only.

CARD8 activator CQ31 is a small molecule that selectively activates CARD8, inhibits the M24B aminopeptidases prolidase (PEPD) and Xaa-Pro aminopeptidase 1 (XPNPEP1), leading to the accumulation of proline-containing peptides that inhibit DPP8/9 and thereby activate CARD8.

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    Biological Activity

    CARD8 activator CQ31 is a small molecule that selectively activates CARD8, inhibits the M24B aminopeptidases prolidase (PEPD) and Xaa-Pro aminopeptidase 1 (XPNPEP1), leading to the accumulation of proline-containing peptides that inhibit DPP8/9 and thereby activate CARD8.

    Physicochemical Properties

    M.Wt 272.345
    Formula C13H24N2O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    methyl ((2S,3R)-3-amino-2-hydroxy-5-methylhexanoyl)-D-prolinate

    References

    1. Sahana D Rao, et al. Nat Chem Biol. 2022 Feb 14.

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