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Chemical Structure : CB-1158
CAS No.: 2095732-06-0
Catalog No.: PC-60274Not For Human Use, Lab Use Only.
CB-1158 (Numidargistat, INCB-001158) is a potent, selective, oral available Arginase inhibitor with IC50 of 98 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $248 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $598 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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CB-1158 (Numidargistat, INCB-001158) is a potent, selective, oral available Arginase inhibitor with IC50 of 98 nM.
CB-1158 (INCB-001158) reduces tumor growth, increases the number of tumor infiltrating CD8+ T-cells, and increases the level of Th1/NK/M1-associated chemokines, cytokines, and activation markers in the tumor microenvironment in combination with checkpoint inhibitors in mice bearing LLC tumors.
CB-1158 (INCB-001158) is a novel immuno-oncology agent targeting the immunosuppressive effects of tumor-infiltrating myeloid cells.
CB-1158 (INCB-001158) has high oral bioavailability.
| M.Wt | 287.123 | |
| Formula | C18H27BCl2N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(3R,4S)-1-(L-alanyl)-3-amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic acid |
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1. Melissa Works, et al. DOI: 10.1158/1538-7445.AM2016-552. AACR.
2. Steggerda SM, et al. J Immunother Cancer. 2017 Dec 19;5(1):101.
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