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Chemical Structure : CB988
Catalog No.: PC-61951Not For Human Use, Lab Use Only.
CB988 is a potent, highly selective, non-covalent Btk inhibitor targering ibrutinib-resistant Btk C481S mutant (IC50=0.6 nM).
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CB988 is a potent, highly selective, non-covalent Btk inhibitor targering ibrutinib-resistant Btk C481S mutant (IC50=0.6 nM).
CB988 inhibits activated Btk and unactivated Btk with IC50 of 0.78 and 0.09 nM, strongly reduces p-Tyr223 and the proliferation of OCI-Ly10 cells.
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10 mM in DMSO |
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