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Chemical Structure : CBI1
Catalog No.: PC-22105Not For Human Use, Lab Use Only.
Covalent BAX inhibitor 1 (CBI1) is a specific, covalent BAX inhibitor selectively derivatizes BAX at Cys126 and inhibits BAX activation by triggering ligands or point mutagenesis.
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Covalent BAX inhibitor 1 (CBI1) is a specific, covalent BAX inhibitor selectively derivatizes BAX at Cys126 and inhibits BAX activation by triggering ligands or point mutagenesis.
CBI1 is not an activator of BAX.
CBI1 demonstrates potent dose-responsive blockade of BAX-mediated liposomal poration upon triggering by the physiologic tBID ligand in liposomal release assay.
CBI1 acts at an upstream control point, specifically the conformational activation step of ligand-triggered monomeric BAX.
CBI1 blocks t-2-hex lipidation and oligomerization of BAX, inhibits BAX activation induced by BH3 ligands, F116A mutagenesis or t-2-hex.
CBI1 not only competes for C126 derivatization to block t-2-hex-mediated BAX sensitization but also independently restrains BAX by stabilizing key structures of its monomeric architecture.
| M.Wt | 415.37 | |
| Formula | C15H19BrN4OS2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Matthew W McHenry, et al. Nat Chem Biol. 2024 Jan 17. doi: 10.1038/s41589-023-01537-6.
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