Chemical Structure : CBI1
CAS No.:
CBI1
(Covalent BAX inhibitor 1)
Catalog No.: PC-22105Not For Human Use, Lab Use Only.
Covalent BAX inhibitor 1 (CBI1) is a specific, covalent BAX inhibitor selectively derivatizes BAX at Cys126 and inhibits BAX activation by triggering ligands or point mutagenesis.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Covalent BAX inhibitor 1 (CBI1) is a specific, covalent BAX inhibitor selectively derivatizes BAX at Cys126 and inhibits BAX activation by triggering ligands or point mutagenesis.
CBI1 is not an activator of BAX.
CBI1 demonstrates potent dose-responsive blockade of BAX-mediated liposomal poration upon triggering by the physiologic tBID ligand in liposomal release assay.
CBI1 acts at an upstream control point, specifically the conformational activation step of ligand-triggered monomeric BAX.
CBI1 blocks t-2-hex lipidation and oligomerization of BAX, inhibits BAX activation induced by BH3 ligands, F116A mutagenesis or t-2-hex.
CBI1 not only competes for C126 derivatization to block t-2-hex-mediated BAX sensitization but also independently restrains BAX by stabilizing key structures of its monomeric architecture.
Physicochemical Properties
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M.Wt
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415.37
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Formula
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C15H19BrN4OS2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(3-((2-aminoethyl)disulfanyl)propyl)-3-(4-bromophenyl)-1H-pyrazole-5-carboxamide
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References
1. Matthew W McHenry, et al. Nat Chem Biol. 2024 Jan 17. doi: 10.1038/s41589-023-01537-6.
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