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Chemical Structure : CBK288679
Catalog No.: PC-72577Not For Human Use, Lab Use Only.
CBK288679 (CBK79) is a novel compound that impairs both protein degradation by the ubiquitin-proteasome system (UPS) and autophagy.
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CBK288679 (CBK79) is a novel compound that impairs both protein degradation by the ubiquitin-proteasome system (UPS) and autophagy.
CBK79 inhibits cell viability of MelJuSo Ub-YFP cells with 72h IC50 of 0.22 uM, CBK79-inflicted cell death was caspase-independent.
CBK79 causes accumulation of ubiquitin-dependent and -independent proteasome substrates.
CBK79 induces non-canonical lipidation of MAP1LC3B/LC3B (microtubule-associated protein 1 light chain 3 beta) that requires ATG16L1 but is independent of the ULK1 and class III phosphatidylinositol 3-kinase (PtdIns3K) complexes.
CBK79 (10 uM) induces proteotoxic stress and the heat shock response in HOS GFP-LC3B cells.
CBK79 has unique features as it inhibits both ubiquitin-dependent and -independent degradation of short-lived proteins by the UPS, as well as the degradation of long-lived proteins by autophagy.
| M.Wt | 282.365 | |
| Formula | C15H14N4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Giovannucci TA, et al. Autophagy. 2021 Nov 5:1-17. doi: 10.1080/15548627.2021.1988359.
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