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Chemical Structure : CBP-93872
Catalog No.: PC-70110Not For Human Use, Lab Use Only.
A potent G2 checkpoint inhibitor that specifically abrogates the DNA double-stranded break (DSB)-induced G2 checkpoint.
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A potent G2 checkpoint inhibitor that specifically abrogates the DNA double-stranded break (DSB)-induced G2 checkpoint; directly suppresses the growth of p53-mutated cancer cell lines with wild-type CDKN2A by eliciting G(1) arrest, but not CDKN2A-deleted and/or wild-type p53 lines; decreases phospho-cdc2 Y15 by inhibiting phosphorylation of Chk1; specifically inhibits DSB-mediated and Nbs1-dependent activation of ATR.
| M.Wt | 259.14 | |
| Formula | C10H15BrN2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Harada N, et al. Anticancer Drugs. 2011 Nov;22(10):986-94.
2. Hirokawa T, et al. Cancer Res. 2014 Jul 15;74(14):3880-9.
3. Iwata T, et al. PLoS One. 2017 May 30;12(5):e0178221.
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