Catalog No.: PC-70110Not For Human Use, Lab Use Only.
CBP-93872 is a potent G2 checkpoint inhibitor that specifically abrogates the DNA double-stranded break (DSB)-induced G2 checkpoint, inhibits NBS1-mediated ATR activation.
CBP-93872 is a potent G2 checkpoint inhibitor that specifically abrogates the DNA double-stranded break (DSB)-induced G2 checkpoint, inhibits NBS1-mediated ATR activation.
CBP-93872 directly suppresses the growth of p53-mutated cancer cell lines with wild-type CDKN2A by eliciting G(1) arrest, but not CDKN2A-deleted and/or wild-type p53 lines.
CBP-93872 decreases phospho-cdc2 Y15 by inhibiting phosphorylation of Chk1.
CBP-93872 specifically inhibits DSB-mediated and Nbs1-dependent activation of ATR.
