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CBP-93872

Chemical Structure : CBP-93872

CAS No.: 67427-51-4

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CBP-93872 (CBP93872;CBP 93872)

Catalog No.: PC-70110Not For Human Use, Lab Use Only.

A potent G2 checkpoint inhibitor that specifically abrogates the DNA double-stranded break (DSB)-induced G2 checkpoint.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A potent G2 checkpoint inhibitor that specifically abrogates the DNA double-stranded break (DSB)-induced G2 checkpoint; directly suppresses the growth of p53-mutated cancer cell lines with wild-type CDKN2A by eliciting G(1) arrest, but not CDKN2A-deleted and/or wild-type p53 lines; decreases phospho-cdc2 Y15 by inhibiting phosphorylation of Chk1; specifically inhibits DSB-mediated and Nbs1-dependent activation of ATR.

Physicochemical Properties

M.Wt 259.14
Formula C10H15BrN2O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-amino-3-((2-bromo-4-methylphenyl)amino)propan-2-ol

References

1. Harada N, et al. Anticancer Drugs. 2011 Nov;22(10):986-94.

2. Hirokawa T, et al. Cancer Res. 2014 Jul 15;74(14):3880-9.

3. Iwata T, et al. PLoS One. 2017 May 30;12(5):e0178221.

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