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Chemical Structure : CBR-5884
CAS No.: 681159-27-3
Catalog No.: PC-42027Not For Human Use, Lab Use Only.
CBR-5884 (CBR5884) is a potent, selective, noncompetitive inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH) with IC50 of 7 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $258 | In stock | |
| 100 mg | Get quote |
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CBR-5884 (CBR5884) is a potent, selective, noncompetitive inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH) with IC50 of 7 uM.
CBR-5884 selectively inhibits de novo serine synthesis in cancer cells with IC50 of 30 uM.
CBR-5884 shows a time-dependent onset of inhibition and disrupted the oligomerization state of PHGDH.
| M.Wt | 336.3861 | |
| Formula | C14H12N2O4S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-Thiophenecarboxylic acid, 5-[(2-furanylcarbonyl)amino]-3-methyl-4-thiocyanato-, ethyl ester |
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1. Mullarky E, et al. Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1778-83.
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