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CBR-5884

Chemical Structure : CBR-5884

CAS No.: 681159-27-3

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CBR-5884 (CBR 5884;CBR5884)

Catalog No.: PC-42027Not For Human Use, Lab Use Only.

CBR-5884 (CBR5884) is a potent, selective, noncompetitive inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH) with IC50 of 7 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CBR-5884 (CBR5884) is a potent, selective, noncompetitive inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH) with IC50 of 7 uM.
CBR-5884 selectively inhibits de novo serine synthesis in cancer cells with IC50 of 30 uM.
CBR-5884 shows a time-dependent onset of inhibition and disrupted the oligomerization state of PHGDH.

Physicochemical Properties

M.Wt 336.3861
Formula C14H12N2O4S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-Thiophenecarboxylic acid, 5-[(2-furanylcarbonyl)amino]-3-methyl-4-thiocyanato-, ethyl ester

References

1. Mullarky E, et al. Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1778-83.

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